build up a bussiness by years of effort and persistence; keep(an enterprise,etc) going by painstaking effort;take great pains to carry on one’s work under difficult circumstances; take no end of pains to do sth; take pains with the work
? 在過去二十年里，他～，堅(jiān)持搞他的科學(xué)試驗(yàn)。In the past twenty years he took no end of pains to persist in his scientific experiments.
慘淡經(jīng)營
take pains to do something; build up a business by laborious effort and persistence;keep an enterprise going by painstaking efforts;take great pains to carry on one’s work under difficult circumstances
慘淡經(jīng)營cǎn dàn jīnɡ yínɡ
慘淡：煞費(fèi)苦心。比喻費(fèi)盡心思謀劃某事。take great pains to carry on one’s work under difficult circumstances, keep going by painstaking effort